Liposome/white-cell interactions in vivo.

The purpose of this study was to establish whether liposomes administered via the intravenous route promote granulocyte aggregation and pulmonary leukostasis. White cells (labelled with [111In]tropolanate) and positively and negatively charged liposomes (containing entrapped [99mTc]DTPA) were administered i.v. to rats. The blood clearance and tissue distribution of 111In label was not altered by the administration of liposomes (and vice versa) and it is inferred that on intravenous liposome administration liposome/white-cell interactions are unlikely to compromise lung function.